Anesthesia of mandibular teeth in adults by the infiltration method would be achieved best by which of the following options?

The best choice for achieving anesthesia of mandibular teeth in adults using the infiltration method is Articaine 4% with epinephrine 1:100,000. Articaine is particularly effective for infiltrative anesthesia in the mandible due to its unique chemical properties, which allow it to diffuse through the dense cortical bone of the mandible more effectively than many other local anesthetics.

Articaine has a higher lipid solubility compared to other agents, enhancing its potency and duration of action. The inclusion of epinephrine as a vasoconstrictor in the solution prolongs the anesthetic effect and reduces systemic absorption, which is especially beneficial in maintaining localized numbing. This combination, therefore, increases the likelihood of successful anesthesia for procedures involving mandibular teeth.

In contrast, while other anesthetics may provide effective pain control, they are generally less effective in achieving successful anesthesia in the mandible through infiltration alone. For example, Bupivacaine, with its longer duration but lesser infiltration efficacy in areas with denser bone, may not provide the same level of effectiveness in this specific application. Similarly, Prilocaine and Mepivacaine, while effective anesthetics, do not have the same tissue penetration capabilities as Art