Which of the following drugs is NOT a treatment option for varicella zoster (shingles)?

Fluconazole is not a treatment option for varicella zoster virus (VZV), which causes shingles. The primary recommended antiviral medications for treating shingles include acyclovir and valacyclovir, both of which are effective in reducing the severity and duration of the infection. These antivirals work by inhibiting the replication of the virus, thereby helping to alleviate symptoms and prevent complications.

Prednisone, a corticosteroid, may also be considered in some cases to reduce inflammation and pain associated with shingles, particularly if the rash is extensive or if the patient is experiencing severe symptoms. However, fluconazole is an antifungal medication and is not effective against viral infections like VZV. Thus, it is the only option listed that is not pertinent to the treatment of shingles.